CAS 128625-52-5 Product Information

Synonyms

CAS 128625-52-5 applications

1. Peptide Synthesis: Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (PyBOP) is commonly used as a coupling reagent in peptide synthesis. It facilitates the formation of peptide bonds between amino acid residues, improving the efficiency and yield of peptide synthesis reactions.
2. Organic Synthesis: PyBOP is a versatile reagent in organic synthesis. It can be used as a coupling agent for the formation of amide, ester, or carbamate bonds. It is particularly useful in reactions involving nucleophiles such as amines, alcohols, or carboxylic acids.
3. Solid-Phase Peptide Synthesis: PyBOP is often employed in solid-phase peptide synthesis (SPPS) as a coupling reagent. It enables the stepwise assembly of peptide chains on a solid support, facilitating the synthesis of peptides with high purity and efficiency.
4. Drug Discovery and Development: PyBOP is utilized in the pharmaceutical industry for the synthesis of small molecule drug candidates and peptide therapeutics. It enables the efficient synthesis of peptide-based drugs and drug conjugates that can exhibit enhanced pharmacokinetic properties or targeted delivery.
5. Other Applications: PyBOP may find use in other areas of chemical research and development. It can be employed in the synthesis of bioconjugates, peptide mimetics, or modified nucleosides. Additionally, it can serve as a reagent in the synthesis of specialty chemicals and materials.